Questions?
| List of Publications That Used A DE Detector | PI | Institution | Camera | EM Mfg | EM Model | Category | Application | Year | Journal | Website | Impact |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Large Area, High Resolution Mapping of Approximate Rotational Symmetries in a Pd77.5Cu6Si16.5 Metallic Glass Thin Film | Voyles, Paul | U Wisconsin | Celeritas | TFS | Titan 300/80 | Materials | 4D STEM | 2021 | Ultramicroscopy | View | First Celeritas paper! High resolution symmetry mapping of local order in a metallic glass |
| Liquid-EM goes viral - visualizing structure and dynamics | Kelly, Deb | Penn State | DE-12 | TFS | Talos | Biology | In situ | 2022 | Current Opinion in Structural Biology | View | Explains and demonstrates importance of liquid holders and direct detectors for bio applications |
| A mechanism for exocyst-mediated tethering via Arf6 and PIP5K1C-driven phosphoinositide conversion | Bhella, David | U Glasgow | DE-64 | JEOL | CryoARM300 | Biology | CryoEM | 2022 | Current Biology | View | Cryo tomography |
| Light-induced hexatic state in a layered quantum material | Claus Ropers | U Gottingen | DE-16 | JEOL | UTEM | Physics | Ultrafast TEM | 2022 | arXiv | View | Low dose diffraction tomography on DE-16 |
| Cryoem Structure Determination of Actin Decorated with Smooth Muscle Heavy Meromyosin | Taylor, Kenneth | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2022 | SSRN Preprint | View | |
| Isolation and Characterization of Lytic Proteus Virus 309 | ??????? | Cape Town | DE-16 | TFS | Tecnai F20 | Biology | Negative Stain | 2022 | Viruses | View | Bio application of DE-16 |
| Emerging Disordered Layered-Herringbone Phase in Organic Semiconductors Unveiled by Electron Crystallography | Koji Yonekura | RIKEN | DE-64 | JEOL | CryoARM300 | Materials | MicroED | 2022 | Chem Mater | View | MicroED on a DE-64 of an organic semiconductor material |
| Switchable wetting of oxygen-evolving oxide catalysts | Tileli, Vasiliki | EPFL | DE-16 | JEOL | 2200FS | Materials | In situ Liquid | 2022 | Nature Catalysis | View | In situ electrochemistry on wettability of an oxide (with zero-loss energy filtering) |
| Automated Tools to Advance High-Resolution Imaging in Liquid | Kelly, Deb | Penn State | DE-12 | TFS | Talos | Biology | In situ | 2022 | Microscopy and Microanalysis | View | Cryo-EM methods applied to liquid cell EM |
| Reversed Phase Transformation of β→α-Sn at Elevated Temperatures towards Quantum Material Integration on Silicon | Gardener, Jules/Liu, Jifeng | Harvard / Dartmouth | DE-16 | JEOL | ARM | Materials | 4D STEM | 2022 | Communications Materials | View | Example of crystal phase mapping with 4D STEM on a DE camera. Also first paper from Harvard!!!! |
| Rigid monoclonal antibodies improve detection of SARS-CoV-2 nucleocapsid protein | Patricia Grob | UC Berkeley | DE-12 | TFS | Tecnai F20 | Biology | Negative Stain | 2021 | mAbs | View | Covid-related research |
| Machine learning-based real-time object locator/evaluator for cryo-EM data collection | Koji Yonekura | RIKEN | DE-64 | JEOL | CryoARM300 | Biology | CryoEM | 2021 | Nature Communications Biology | View | Machine Learning applied to automate cryoEM data collection |
| High temporal-resolution scanning transmission electron microscopy using sparse-serpentine scan pathways | De Jonge, Niels | Leibniz Institute | None (Freescan) | JEOL | ARM 200F | Both | In situ | 2021 | Scientific Reports | View | Serpentine scanning and sparse sampling demoed with Freescan |
| Fast Surface Dynamics on a Metallic Glass Nanowire | Voyles, Paul | U Wisconsin | DE-16 | TFS | Titan 300/80 | Materials | In situ | 2021 | ACS Nano | View | Rapid In situ heating with a DENS holder. |
| Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV | ??????? | Cape Town | DE-16 | TFS | Tecnai F20 | Biology | Negative Stain | 2021 | Vaccines | View | Bio-TEM on a DE-16 |
| Electron crystallography of chiral and non-chiral small molecules | Chiu, Wah | Stanford | DE-64 | TFS | Talos Arctica 200 | Biology | MicroED | 2021 | Ultramicroscopy | View | MicroED on a DE-64, continuous rotation |
| Ultrafast electron microscopy for probing magnetic dynamics | Claus Ropers | U Gottingen | DE-16 | JEOL | UTEM | Physics | Ultrafast TEM | 2021 | MRS Bulletin | View | Example of Ultrafast 4D STEM for magnetic imaging. |
| Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes | ?????? | U Indianna | DE-12 | JEOL | JEM 3200FS | Biology | CryoEM | 2021 | Journal of Virology | View | |
| In situ electron microscopy study of structural transformations in 2D CoSe2 | ?????? | Delft University | DE-16 | TFS | Titan 300/80 | Materials | In situ Heating | 2021 | npj 2D Materials | View | In situ heating at atomic resolution showing phase change in Cobalt Di-Selenide |
| High-Resolution Imaging of Human Viruses in Liquid Droplets | Kelly, Deb | Penn State | DE-12 | TFS | Talos | Biology | In situ Liquid | 2021 | Advanced Materials | View | Single Particle In Situ Liquid EM as alternative to Cryo EM |
| Direct Detectors and Their Applications in Electron Microscopy for Materials Science | Levin, Barnaby | Direct Electron | DE-16, DE SEMCam | JEOL, TFS | Materials | Low dose HRTEM, In situ, EBSD, 4D STEM, EELS | 2021 | Journal of Physics : Materials | View | Review article on direct detectors in materials science | |
| Elemental mapping of labelled biological specimens at intermediate energy loss in an energy-filtered TEM acquired using a direct detection device | Ellisman, Mark | UC San Diego | DE-12 | JEOL | JEM 3200EF | Biology | CryoEFTEM | 2021 | Journal of Microscopy | View | Demonstration of low dose elemental mapping with one of our cameras |
| The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the Vesivirus genus | Bhella, David | U Glasgow | DE-64 | JEOL | CryoARM300 | Biology | CryoEM | 2021 | Journal of Virology | View | |
| The myosin II coiled-coil domain atomic structure in its native environment | Taylor, Kenneth | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2021 | PNAS | View | |
| trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo | Stagg, Scott | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2021 | Nature Communications | View | |
| Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy | Kelly, Deb | Penn State | DE-12 | TFS | Talos | Biology | CryoEM | 2021 | Nanoscale | View | Cryo-EM of Sars-CoV2 Virus (Covid virus) Spike Protein |
| Three-step nucleation of metal–organic framework nanocrystals | Mirsaidov, Utkur | NU Singapore | DE-16 | JEOL | 2200FS | Materials | In situ | 2021 | PNAS | View | Extreme Low Dose In Situ TEM of MOFs |
| A data reduction and compression description for high throughput time-resolved electron microscopy | Loh, Duane | NU Singapore | DE-16 | JEOL | 2200FS | Materials | In situ | 2021 | Nature Communications | View | Advanced algorithms for high speed in situ TEM |
| Protein and Organic-Molecular Crystallography With 300kV Electrons on a Direct Electron Detector | Yonekura, Koji | RIKEN | DE-64 | JEOL | CryoARM300 | Biology | CryoEM | 2021 | Frontiers in Molecular Biosciences | View | |
| Real-time Monitoring Reveals Dissolution/Redeposition Mechanism in Copper Nanocatalysts during the Initial Stages of the CO2 Reduction Reaction | Tileli, Vasiliki | EPFL | DE-16 | JEOL | 2200FS | Materials | In situ Liquid | 2021 | Angewandte Chemie | View | In situ TEM of Carbon Dioxide Reduction over Copper Nanocatalysts |
| Supertwisted spirals of layered materials enabled by growth on non-Euclidean surfaces | Voyles, Paul | U Wisconsin | DE-16 | TFS | Titan 300/80 | Materials | 4D STEM | 2020 | Science | View | High Impact Publication. High Quality Nanodiffraction demonstrated on DE-16 |
| CryoEM structure of Drosophila flight muscle thick filaments at 7 A resolution | Taylor, Kenneth | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2020 | Life Science Alliance | View | |
| Mechanism of efficient double-strand break repair by a long non-coding RNA | ???? | Baylor College of Medicine | DE-64 | JEOL | 2200FS | Biology | CryoEM | 2020 | Nucleic Acids Research | View | |
| Denoising atomic resolution 4D scanning transmission electron microscopy data with tensor singular value decomposition | Voyles, Paul | U Wisconsin | DE-16 | TFS | Titan 300/80 | Materials | 4D STEM | 2020 | Ultramicroscopy | View | Rapid Denoising of 4D STEM data improves quality |
| 60S subunit joining exposes nascent pre-40S rRNA for quality control | M. Elizabeth Stroupe | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2020 | biorXiv | View | |
| An opened pre-40S platform enables regulation of Fap7 late in ribosomal assembly | M. Elizabeth Stroupe | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2020 | biorXiv | View | |
| Ultrafast nano-imaging of the order parameter in a structural phase transition | Claus Ropers | U Gottingen | DE-16 | JEOL | UTEM | Physics | Ultrafast TEM | 2020 | Science | View | High Impact Paper. Ultrafast, real space dark field imaging of different crystalline phases |
| Electron Backscattered Diffraction using a New Monolithic Direct Detector: High Resolution and Fast Acquisition | Gianola, Dan | UC Santa Barbara | DE-SEMCam | TFS | Apreo | Materials | EBSD | 2020 | Ultramicroscopy | View | EBSD at ~6000 fps with AKRA |
| Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8 | McKenna, Mavis | U Florida/FSU | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2020 | Journal of Virology | View | 2.75 Angstrom resolution |
| High-purity free-electron momentum states prepared by three-dimensional optical phase modulation | Ropers, Claus | U Gottingen | DE-16 | JEOL | UTEM | Physics | Ultrafast TEM | 2020 | Phys. Rev. Research | View | Control of electron beam momentum states using laser beam |
| Reconstruction of Average Subtracted Tubular Regions (RASTR) enables structure determination of tubular filaments by cryo-EM | Stagg, Scott | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2020 | Journal of Structural Biology | View | High-resolution CryoEM of challenging structures |
| Atomic resolution convergent beam electron diffraction analysis using convolutional neural networks | Voyles, Paul | U Wisconsin | DE-16 | TFS | Titan | Materials | 4D STEM | 2020 | Ultramicroscopy | View | 4D-STEM |
| How Mn/Ni ordering controls electrochemical performance in high-voltage spinel LiNi0.44Mn1.56O4 with fixed oxygen content | Ahmadi, Majid | Delft University | DE-16 | TFS | Titan 300/80 | Materials | Low dose HRTEM | 2020 | ACS Applied Energy Materials | View | Atomic resolution imaging of beam sensitive battery materials |
| Cross-sectional characterization of the conversion layer formed on AA2024-T3 by a lithium-leaching coating | Zandbergen, Henry | Delft University | DE-16 | TFS | Titan 300/80 | Materials | Low dose HRTEM | 2020 | Applied Surface Science | View | Low dose HRTEM imaging of beam sensitive alloy |
| In situ observation of temperature-dependent atomistic and mesoscale oxidation mechanisms of aluminum nanoparticles | ??? | Zhejiang University | DE-12 | Hitachi | 9500 ETEM | Materials | In situ Gas Heating | 2020 | Nano Research | View | In situ oxidation observed on DE-12 |
| Electrode roughness dependent electrodeposition of sodium at the nanoscale | Zhang, Haimei | Lawrence Berkeley National Lab | DE-12 | JEOL | 2100 | Materials | In situ Liquid | 2020 | Nano Energy | View | In situ Electrochemistry on DE-12 |
| Utilizing TiO2 amorphous precursors for polymorph selection: An in situ TEM study of phase formation and kinetics | Gorman, Brian | School of Mines Colorado (using TEM at Hummingbird) | DE-12 | JEOL | 2100 | Materials | In situ Gas Heating | 2020 | J. Am. Ceram. Soc. | View | In situ Gas and Heating at Hummingbird |
| 4D STEM with a direct electron detector | Voyles, Paul | U Wisconsin | DE-16 | TFS | Titan 300/80 | Materials | 4D STEM | 2020 | Microscopy & Analysis | View | 4D STEM explainer written with Paul Voyles. Show off some DE-16 data. |
| Fast Coalescence of metallic glass nanoparticles | Mingwei Chen | Tohoku University | DE-12 | JEOL | JEM2100F | Materials | In situ Heating | 2019 | Nature Communications | View | In situ heating with DE-12 |
| Cryo-electron microscopy: an introduction to the technique, and considerations when working to establish a national facility | Bhella, David | U Glasgow | DE-64 | JEOL | CryoARM300 | Biology | CryoEM | 2019 | Biophysical Reviews | View | Lumazine Synthesaze Reconstruction |
| Yeast R2TP Interacts with Extended Termini of Client Protein Nop58p | Stagg, Scott | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2019 | Scientific Reports | View | |
| Split-miniSOG for Spatially Detecting Intracellular Protein-Protein Interactions by Correlated Light and Electron Microscopy | Ellisman, Mark | UC San Diego | DE-12 | JEOL | JEM 3200EF | Biology | CryoEFTEM | 2019 | Cell Chemical Biology | View | EFTEM using a DE-12 with Omega filter |
| Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue | McKenna, Mavis | U Florida/FSU | DE-20 | TFS | Titan Krios | Biology | CryoEM | 2019 | Molecular Therapy | View | 3.16 Angstrom resolution |
| Direct Observations of the Rotation and Translation of Anisotropic Nanoparticles Adsorbed at a Liquid–Solid Interface | Mirsaidov, Utkur | NU Singapore | DE-16 | JEOL | 2200FS | Materials | In situ Liquid | 2019 | Nano Letters | View | 300 FPS rotating nanorods |
| Time-resolved atomic-scale observations of deformation and fracture of nanoporous gold under tension | Chen, Mingwei | Tohoku University | DE-12 | JEOL | JEM 2100F | Materials | In situ deformation | 2019 | Acta Materialia | View | Time resolved atomic resolution movies |
| Throughput and Resolution with a Next Generation Direct Electron Detector | Stagg, Scott | Florida State U | DE-64 | TFS | Titan Krios | Biology | CryoEM | 2019 | BioRxiv | View | DQE >> Throughput DE-64 on Titan Krios |
| Microstructure and microchemistry study of irradiation-induced precipitates in proton irradiated ZrNb alloys | Voyles, Paul | U Wisconsin | DE-16 | TFS | Titan | Materials | 4D STEM | 2019 | Acta Materialia | View | 4D-STEM |
| Initial Results from the CryoARM300 and DE-64 Counting | Bhella, David | U Glasgow | DE-64 | JEOL | CryoARM300 | Biology | CryoEM | 2019 | Microscopy and Microanalysis | View | Advanced CryoTEM DE-64 on JEOL CryoARM300 |
| Subsampled Acquisition to Increase Speed and Reduce Data Size for In Situ TEM | Browning, Nigel | U Liverpool | DE-16 | JEOL | 2100F | Materials | Compressive Sensing | 2019 | Microscopy and Microanalysis | View | Advanced 4D-STEM with Compressive sensing |
| Multi-Color Electron Microscopy of Cellular Ultrastructure Using 4D-STEM | Ellisman, Mark | UC San Diego | DE-16 | Biology | 4D STEM | 2019 | Microscopy and Microanalysis | View | Biological application of 4D-STEM | ||
| Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR | Stagg, Scott | Florida State U | DE-20 | TFS | Titan Krios | Biology | CryoEM | 2019 | eLife Sciences | View | cryoelectron tomography and SPA - also includes data from Falcon |
| Visualization of unstained DNA nanostructures with advanced in-focus phase contrast TEM techniques | Zandbergen, Henry | Delft University | DE-16 | TFS | Titan 300/80 | Biology | CryoEM | 2019 | Scientific Reports | View | Dark-field TEM on a direct detector |
| Mechanistic Understanding of the Growth Kinetics and Dynamics of Nanoparticle Superlattices by Coupling Interparticle Forces from Real-Time Measurements | Li, Dongsheng | Pacific Northwest National Lab | DE-12 | TFS | Tecnai F20 | Materials | In situ Liquid | 2018 | Nano Letters | View | Superlattice structures formed by nanoparticle (NP) self-assembly |
| 3-D Structure of Z-disks Isolated from the Flight Muscle of Lethocerus indicus | Taylor, Kenneth | Florida State U | DE-20 | TFS | Titan Krios | Biology | CryoEM | 2018 | Biophysical Journal | View | cryoelectron tomography |
| Heating-Induced Transformations of Atmospheric Particles: Environmental Transmission Electron Microscopy Study | Kovarik, Libor | PNNL | DE-12 | TFS | Titan ETEM | Materials | In situ Gas | 2018 | Analytical Chemistry | View | In situ ETEM on DE-12 |
| Structural Insights into Human Bocaparvoviruses | McKenna, Mavis | U Florida/FSU | DE-20 | TFS | Titan Krios | Biology | CryoEM | 2017 | Journal of Virology | View | 2.8 Angstrom resolution |
| Mechanism of ribosome rescue by ArfA and RF2 | Korostelev, Andrei | U Mass Medical School/FSU | DE-20 | TFS | Titan Krios | Biology | CryoEM | 2017 | eLife Sciences | View | 3.15 A resolution on DE-20 |
| An In situ TEM study of the surface oxidation of palladium nanocrystals assisted by electron irradiation | ??? | Zhejiang University | DE-12 | Hitachi | 9500 ETEM | Materials | In situ Gas | 2017 | Nanoscale | View | In situ ETEM at atomic resolution with DE-12 |
| Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species | Ellisman, Mark | UC San Diego | DE-12 | JEOL | JEM 3200EF | Biology | CryoEFTEM | 2016 | Cell Chemical Biology | View | EFTEM using a DE-12 with Omega filter |
| Big Data Analytics for Scanning Transmission Electron Microscopy Ptychography | Lupini, Andrew | Oak Ridge National Lab | DE-12 | TFS | Titan 300/80 | Materials | 4D STEM | 2016 | Scientific Reports | View | 4D STEM on a DE-12 |
| Linker-Mediated Self-Assembly Dynamics of Charged Nanoparticles | Mirsaidov, Utkur | NU Singapore | DE-12 | JEOL | JEM 2200FS | Materials | In situ Liquid | 2016 | ACS Nano | View | 100 fps in situ movies on the DE-12 |
| Catadioptric aberration correction in cathode lens microscopy | Ruud Tromp | IBM Watson | LV-126 | Custom | Custom | Materials | LEEM | 2015 | Ultramicroscopy | View | Image from LV-126. Description of installation |
| Promotion of virus assembly and organization by the measles virus matrix protein | Wright, Elizabeth | Emory University | DE-20 | JEOL | JEM 2200FS | Biology | CryoEM | 2015 | Nature Communications | View | |
| In Situ Study of Lithiation and Delithiation of MoS2 Nanosheets Using Electrochemical Liquid Cell Transmission Electron Microscopy | Zhang, Haimei | Lawrence Berkeley National Lab | DE-12 | Materials | In situ Liquid | 2015 | Nano Letters | View | Electrochemistry | ||
| In situ TEM study of the Li–Au reaction in an electrochemical liquid cell | Zhang, Haimei | Lawrence Berkeley National Lab | DE-12 | Materials | In situ Liquid | 2015 | Faraday Discussions | View | |||
| An atomic model of brome mosaic virus using direct electron detection and real-space optimization | Chiu, Wah | Baylor College of Medicine | DE-12 | JEOL | 3200FSC | Biology | CryoEM | 2014 | Nature Communications | View | 3.8 Å |
| Beam-induced motion of vitrified specimen on holey carbon film | Brilot, Axel | Brandeis U | DE-12 | Biology | CryoEM | 2012 | Journal of Structural Biology | View | First Cryo-EM Motion Correction - Journal of Structural Biology Paper of the Year | ||
| Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency | Chiu, Wah | Baylor College of Medicine | DE-12 | Biology | CryoEM | 2012 | Journal of Structural Biology | View | First Cryo-EM Reconstruction Near Nyquist | ||
| Initial evaluation of a direct detection device detector for single particle cryo-electron microscopy | Ellisman, Mark | UC San Diego | DE-12 | Biology | CryoEM | 2011 | Journal of Structural Biology | View | First DDD publication |