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Publications

Highlighted Publications

SEARCHABLE LIBRARY

Publication TitleYearCameraEM ManufacturerEM ModelCategoryGeneral ApplicationSpecific TechniqueJournalWebsiteImpact
Beam teleportation for precision dose control in scanning transmission electron microscopy2026None (DE-Freescan)JEOLGrand ARMMaterialsOtherSTEM imagingUltramicroscopyViewDE FreeScan used in conjunction with IDES Synchrony and EDM to perform distributed scanning with ultrafast beam blanking between scan points, minimizing beam damage. The beam appears to teleport from the point of view of the specimen.
Cryo-EM of a Divergent Herpesvirus Reveals Structural Conservation and Novelty Including a Portal-Vertex Tegument Protein with Multiple Macrodomain-like Folds2026ApolloJEOLCryoARM300BiologyCryoEMSingle-particle CryoEMbioRxivView
Myosin Filaments of Vertebrate Skeletal and Cardiac Muscle are Highly Similar, but not Identical2026ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMbioRxivView
Demonstration of in vivo efficacy, cryo-EM-epitope identification, and breadth of two anti-alphavirus bispecific single domain antibodies2026ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMJournal of VirologyView
Short-range order in high entropy carbides2026Celeritas XSTFSTitan 200/80Materials4D STEMStrain mappingNature CommunicationsView4D STEM was used to map strain in high entropy carbides that where observed to exhibit chemical short range order
Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses2025ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMNature MicrobiologyViewThis research identifies and characterizes antibodies against diverse H5Nx viruses from individuals who received a monovalent H5N1 vaccine 15 years ago. Several highly potent antibodies are identified, and this can aid pandemic preparedness against the threat of an H5Nx influenza outbreak.
Spatially Aware Diffraction Mapping Enables Fully Autonomous MicroED2025ApolloTFSTalos F200CBiologyCryoEMMicroEDJACSViewDevelopment of an autonomous MicroED dataset collection software package that makes use of the high speed of Apollo
Room temperature structures of solvated organic molecules enabled by liquid cell electron diffraction2025ApolloTFSTalos F200CBiologyCryoEMMicroEDChemRxivView
Applications of Event-Based Direct Detectors in Cryo-Electron Microscopy2025ApolloMultipleMultipleBiologyCryoEMEvent-based detectorsMicroscopy TodayViewReview of results in CryoEM, CryoET, and MicroED achieved using the Apollo detector
Structure of dimerized assimilatory NADPH-dependent sulfite reductase reveals the minimal interface for diflavin reductase binding2025ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMNature CommunicationsViewFirst report of the structure of a sulfite reductase/oxidase complex, with key insights into interactions at the interface.
Detection of non-native species formed during fibrillization of the myocilin olfactomedin domain2025ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMProtein ScienceViewThe structure of Myocilin C-terminal olfactomedin domain, which is relevant for the pathogenesis of glaucoma, was characterized by multiple techniques, including cryo-EM
HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors2025ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMNature CommunicationsViewThis study identifies the receptor site for a form of bat coronavirus, merbecovirus HKU5, and finds that the virus can engage these receptor sites mink and stoats as well, revealing mustelids as potential intermediate hosts for spillover.
A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor2025ApolloJEOLCryoARM300BiologyCryoEMSingle-particle CryoEMRSC Chem BiolViewCryo-EM shows the structure of encapsulated nitroreductase NfsB dimers within a nanoreactor enviroment. The findings highlight the potential of encapsulins as tools for enhancing enzyme performance.
Combining MicroED and native mass spectrometry for structural discovery of enzyme–small molecule complexes2025ApolloTFSTalos F200CBiologyCryoEMMicroEDPNASView
Fast event-based electron counting for small-molecule structure determination by MicroED2025ApolloTFSTalos F200CBiologyCryoEMMicroEDActa CrystViewCharacterization of the Apollo detector for MicroED, finding that high resolution 3D reconstructions can be produced from data collected in ~50 seconds.
Ion beam assisted deposition of a thin film metallic glass2025Celeritas XSTFSTitan 200/80MaterialsOtherNanobeam Electron DiffractionThin Solid FilmsViewStudy of ion beam assisted deposition, which can yield metallic glasses with improved kinetic stability and hardness, and offers new ways to tune the structure and properties of metallic glasses
Energy-Resolved EBSD using a Monolithic Direct Electron Detector2025DE-SEMCamTFSApreoMaterialsLow kVEBSDarXivViewFirst use of a MAPS detector to record energy-resolved EBSD datasets and use them to produce high resolution EBSD patterns
Fast nanothermometry based on direct electron detection of electron backscattering diffraction patterns2025DE-SEMCamTFSApreoMaterialsLow kVEBSDarXivViewUse of width of Kikuchi Bands in high-resolution EBSD patterns to measure local specimen temperature
Orientation-adaptive virtual imaging of defects using EBSD2025DE-SEMCamTFSApreoMaterialsLow kVEBSDUltramicroscopyViewFirst use of a dynamic array of virtual apertures to map dislocations in single and polycrystalline materials with EBSD
Direct electron detection for EBSD of low symmetry & beam sensitive ceramics2025DE-SEMCamTFSApreoMaterialsLow kVEBSDUltramicroscopyViewMAPS Direct detector yields superior EBSPs of low symmetry, charge-sensitive ceramics
Synthesis of immunomodulatory biomimetic lipid polymer hybrid nanoparticles and application of zebrafish larvae in immunomodulation screening2025DE-16TFSTecnai F20BiologyOtherNegative stain TEMEuropean Journal of Pharmaceutical SciencesViewThis work provided insights into the use of zebrafish larvae for investigating nanoparticle immunotherapies
Trapping and imaging dynamic battery nanointerfaces via electrified cryo-EM2025DE-64TFSTitan 300/80MaterialsCryoEMHRTEMScience AdvancesViewFirst demonstration of "electrified Cryo-EM (eCryo-EM) where batteries are vitrified during operation, allowing for snapshots of the solid electrolyte interphase (SEI) layer
KRASG12D-Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC Patients2025DE-64JEOL2200FSBiologyCryoEMSingle-particle CryoEMmedRxivView
Nanoscale View of Alignment and Domain Growth in a Hexagonal Columnar Liquid Crystal2024Celeritas XSTFSTitan 200/80Materials4D STEMOrientation MappingACS Nano ViewIn situ 4D STEM was used to characterize structural changes in a liquid crystal material as a function of temperature
Clustering characteristic diffraction vectors in 4-D STEM data sets from overlapping structures in nanocrystalline and amorphous materials2024Celeritas XSTFSTitan 200/80Materials4D STEMOrientation MappingUltramicroscopyViewMethodology to identify and cluster diffraction patterns in 4D datasets to allow for complex structural analysis of materials such as metallic glass.
From Beam Damage to Massive Reaction Amplification under the Electron Microscope: An Ionization-Induced Chain Reaction in Crystals of a Dewar Benzene2024ApolloTFSTalos F200CBiologyCryoEMMicroEDACS Central ScienceViewThe study shows how chemical probes can be used to transform indiscriminate electron beam damage into clean chemical processes that help to characterize electron beam - soft organic matter interactions.
Accounting for electron-beam-induced warping of molecular nanocrystals in MicroED structure determination2024ApolloTFSTalos F200CBiologyCryoEMMicroEDIUCrJViewFundamental study of beam-induced crystal lattice reorientations, and how these must be accounted for in MicroED
Conformational Flexibility in Capsids Encoded by the Caliciviridae2024ApolloJEOLCryoARM300BiologyCryoEMSingle-particle CryoEMVirusesViewA review, summarizing current understanding of capsid protein P-domain flexibility, and the role it plays in infection and immune evasion by calciviruses, which include norovirus.
The Structure of the Drp1 Lattice on Membrane2024ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMbioRxivViewA locally ordered Drp1 lattice structure is solved and reveals intermolecular contacts and conformational rearrangements that suggest a mechanism for constriction of mitochondrial membranes
Nanoscale Operando Imaging of Electrically Driven Charge-Density Wave Phase Transitions2024DE-16JEOLJEM 2100 UTEMPhysicsOtherUltrafast TEMNano LettersViewUltrafast TEM was used to image a current-induced phase transformation in the charge-density wave (CDW) material 1T-TaS2
2D Electrodes From Functionalized Graphene for Rapid Electrochemical Gold Extraction and Reduction From Electronic Waste2024DE-16JEOLJEM 2200FSMaterialsOtherLow dose HRTEMAdvanced ScienceViewDE-16 used to image gold nanoparticles produced after electro-extraction from waste electronics
Graphene/chitosan nanoreactors for ultrafast and precise recovery and catalytic conversion of gold from electronic waste2024DE-16JEOLJEM 2200FSMaterialsOtherLow dose HRTEMPNASViewDE-16 used to image gold nanoparticles produced after electro-extraction from waste electronics
Enhanced Efficiency and Stability for the Inverted High-Bandgap Perovskite Solar Cell via Bottom Passivation Strategy2024DE-16JEOLF200MaterialsOtherLow dose HRTEMRRL SolarViewLow-dose lattice resolution images were acquired to characterize the structure of a perovskite solar cell material
Gold nanoparticles decorated magnetic nanozyme for colorimetric detection of mercury (II) ions via enhanced peroxidase-like activity2024DE-16TFSTecnai F20MaterialsOtherLow dose HRTEMMicrochemical JournalViewGold-loaded ZnO/Fe3O4 nanozymes developed for use in detecting mercury contamination
Femtosecond trimer quench cycled at megahertz rates in the unconventional charge-density wave material 1T′-TaTe22024DE-16JEOLJEM 2100 UTEMPhysicsOtherUltrafast TEMPhys Rev BViewA strongly directional cooperative atomic motion is observed on a 500 fs timescale is observed during a one-dimensional quench of a transition metal dichalcogenide at low temperature.
Effects of Thiophene-Fused Isomer on High-Layered Crystallinity in π-Extended and Alkylated Organic Semiconductors2024DE-64JEOLCryoARM300MaterialsCryoEMMicroEDChem MaterView
Emergence of mixing-induced polymorphic phase with higher mobility in alkylated layered organic semiconductors2024DE-64JEOLCryoARM300MaterialsCryoEMMicroEDPhysical Review MaterialsView
Structure-guided mutagenesis targeting interactions between pp150 tegument protein and small capsid protein identify five lethal and two live-attenuated HCMV mutants2024DE-64TFSTitan 300/80BiologyCryoEMSingle-particle CryoEMVirologyViewMutational analysis of the pp150 small capsid protein interface in human cytomegalovirus
Scalable electron tomography for connectomics2024DE-64TFSTitan HaloBiologyOtherSerial Section TomographybioRxivViewThe authors demonstrate limited-tilt, serial section electron tomography (ET), which can non-destructively map brain circuits over large 3D volumes
Effects of Thiophene-Fused Isomer on High-Layered Crystallinity in π-Extended and Alkylated Organic Semiconductors2024DE-64JEOLCryoARM300MaterialsCryoEMMicroEDChem. MaterViewSystematic investigation of the structure of highly layered organic semiconductors
Adult cardiomyocytes-derived EVs for the treatment of cardiac fibrosis2024DE-20JEOLJEM 2200FSBiologyCryoEMLow dose HRTEMJournal of Extracellular VesiclesViewAnalysis of extracellular vesicles released by cardiomyocytes, which may offer a treatment for cardiac fibrosis
Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å2024DE-20JEOLJEM 2200FSBiologyCryoEMSingle-particle CryoEMScientific ReportsViewPhase-plate assisted single particle cryo-EM was applied to a therapeutic immunoglobulin, revealing structure. The approach developed here helps overcome challenges in cryo-EM analysis of small proteins.
Molecular Mechanism of pH-Induced Protrusion Configuration Switching in Piscine Betanodavirus Implies a Novel Antiviral Strategy2024DE-20JEOLJEM-2100FBiologyCryoEMSingle-particle CryoEMACS Infectious DiseasesViewThis work provides new structural insights and identifies a number of putative druggable sites on the capsid protrusion of nervous necrosis virus, which infects fish and causes environmental and economic harm worldwide.
Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology 2024DE-20JEOLJEM 2200FSBiologyCryoEMLow dose HRTEMCommunications MedicineViewThis study demonstrate that small non coding RNAs derived from small extracellular vesicles in follicular fluid can be potential non-invasive biomarkers for predicting pregnancy in assisted reproductive treatments
Crystal plane orientation-dependent surface atom diffusion in sub–10-nm Au nanocrystals2024DE-12JEOLJEM-2100FMaterialsIn situIn situ StrainScience AdvancesViewIn situ TEM was used to observe atomic-scale surface pressure-driven atom diffusion in gold nanocrystals at room temperature
Antibodies from dengue patients with prior exposure to Japanese encephalitis virus are broadly neutralizing against Zika virus2024DE-12JEOLJEM-2100FBiologyCryoEMSingle-particle CryoEMCommunications BiologyViewThis study identified a rare class of ZIKV-cross-reactive human monoclonal antibodies with broad neutralization against multiple flaviviruses
Methylocystis suflitae sp. nov., a novel type II methanotrophic bacterium isolated from landfill cover soil2024DE-12JEOL2010FBiologyCryoEMLow dose HRTEMInternational Journal of Systemic and Evolutionary MicrobiologyViewThis study describes a previously unknown methanotrophic bacterium found in landfill cover soil
Event-based direct detectors and their applications in electron microscopy2023ApolloMultipleMultipleBiologyCryoEMEvent-based detectorsMicroscopy & AnalysisViewThe authors review the development of event-based direct detectors, and their electron microscopy applications.
Effect of self and extrinsic encapsulation on electron resilience of porous 2D polymer nanosheets2023ApolloJEOLNeoARMMaterialsOtherLow dose HRTEMMicronViewThe lattice of a beam sensitive 2D polymer was imaged using Apollo at 5 electrons per angstrom squared. Lattice imaging was impossible on a conventional detector due to beam damage.
Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard2023ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMMolecular Therapy-Methods & Clinical DevelopmentViewThis work describes the design, production, characterization, & CryoEM structure of an AAV1-VP3-only capsid to be used as an analytical standard for gene therapy delivery studies.
Deep Learning Approach for High-accuracy Electron Counting of Monolithic Active Pixel Sensor-type Direct Electron Detectors at Increased Electron Dose2023Celeritas XSTFSTitan 200/80Materials4D STEMOtherMicroscopy and MicroanalysisViewDeep learning algorithm for electron counting developed that can process frames with less sparsity than conventional methods
Vapor-to-glass preparation of biaxially aligned organic semiconductors2023Celeritas XSTFSTitan 200/80Materials4D STEMOrientation MappingJ Chem PhysViewNanometer scale orientation mapping of molecular glasses using low-dose 4D STEM
Momentum transfer resolved electron correlation microscopy2023Celeritas XSTFSTitan 200/80Materials4D STEMIn situ 4D STEMUltramicroscopyViewAn in situ 4D STEM dataset was used to create relaxation time maps for a metallic glass nanowire heated to 511K
Using 4D STEM to Probe Mesoscale Order in Molecular Glass Films Prepared by Physical Vapor Deposition2023Celeritas XSTFSTitan 200/80Materials4D STEMOrientation MappingNano LettersViewNanometer scale orientation mapping of molecular glasses using low-dose 4D STEM
Event-based direct detectors and their applications in electron microscopy2023ApolloMultipleMultipleMultipleOtherReviewMicroscopy & AnalysisViewReview of event-based direct detectors for electron microscopy, including the DE Apollo camera
Dislocation cells in additively manufactured metallic alloys characterized by electron backscatter diffraction pattern sharpness2023DE-SEMCamTFSApreoMaterialsLow kVEBSDMaterials CharacterizationViewUse of EBSD pattern sharpness to characterize dislocation cells
Single-shot, coherent, pop-out 3D metrology2023DE-16JEOLJEM-2200FSMaterialsOtherHRTEMCommunications PhysicsViewThis paper outlines a method for determining the 3D structure of a specimen in TEM by analyzing differences in defocus in different areas of a TEM image
Light-induced hexatic state in a layered quantum material 2023DE-16JEOLJEM 2100 UTEMPhysicsOtherUltrafast TEMNature MaterialsViewLow dose diffraction tomography on a DE-16 to determine a light induced state in a material on ultrafast timescales
Direct atomic-scale observation of thermally driven grain-boundary migration associated with triple-junction motion2023DE-16JEOLJEM-2200FSMaterialsIn situIn situ HeatingPhys. Rev. Mater.ViewDynamics of grain boundaries in a polycrystalline material imaged during heating
Antibacterial and cytotoxicity activity of green synthesized silver nanoparticles using aqueous extract of naartjie (Citrus unshiu) fruit peels2023DE-16TFSTecnai F20BiologyOtherLow dose HRTEMEmerging ContaminantsViewThis study analyzed the antibacterial and cytotoxicity activity of silver nanoparticles synthesized from fruit peels
A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters2023DE-16TFSTecnai F20BiologyOtherNegative Stain TEMFrontiers In Plant ScienceViewA plant-produced SARS-COV-2 antigen was assessed and compared to a similar mammalian-produced antigen
Assessing Ultrathin Wafer-Scale WS2 as a Diffusion Barrier for Cu Interconnects2023DE-16JEOLJEM-2200FSMaterialsOtherHRTEMACS Appl. Electron. Mater.ViewThis study shows that WS2 films block Cu diffusion and reduce the effective resistance of Cu films, with applications to intertconnects in CMOS technology
Physical properties of computationally informed phyto-engineered 2-D nanoscaled hydronium jarosite2023DE-16TFSTecnai F20MaterialsOtherLow dose HRTEMScientific ReportsViewLow dose imaging of a bioengineering-generated rare mineral, hydronium jarosite
Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants2023DE-64TFSTitan KriosBiologyCryoEMSingle-particle CryoEMJournal Of VirologyViewThis study investigates the role of viral protein (VP) symmetry interactions on capsid assembly, genome packaging, stability, and infectivity for adeno-associated viruses, which are key vectors for gene therapy
Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories2023DE-64TFSTitan HaloBiologyOtherResin-embedded TomographyNature CommunicationsViewElectron tomography allowed subcellular volumes of ebolavirus viral factories to be reconstructed and characterized
Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography2023DE-64JEOLCryoARM300BiologyCryoEMMicroEDNature ChemistryViewThe structure of an organic molecule, rhodamine-6G, was determined by both XFEL, and by electron diffraction using a direct detector
Structural Characterization of Canine Minute Virus, Rat and Porcine Bocavirus2023DE-64TFSTitan KriosBiologyCryoEMSingle-particle CryoEMVirusesViewThe capsid structures of several Bocaparvoviruses, for which no antivirals or vaccines currently exist, were determined by CryoEM.
Double-headed binding of myosin II to F-actin shows the effect of strain on head structure2023DE-64TFSTitan KriosBiologyCryoEMSingle-particle CryoEMJ Struct BioViewCryoEM used to visualize internal strain produced in F-actin with heavy meromyosin
Quantification of monodisperse and biocompatible gold nanoparticles by single-particle ICP-MS2023DE-12JEOLJEM-2010FMaterialsOtherLow dose HRTEMAnalytical and Bioanalytical ChemistryViewInvestigation of how different synthesis methods affect gold nanoparticle size distribution and cytotoxicity
Fabrication of liquid cell for in situ transmission electron microscopy of electrochemical processes2023DE-12JEOLJEM-2100FMaterialsIn situLiquid phase EMNature ProtocolsViewMethodology review article featuring figures showing data acquired on a DE-12 detector
Structure and its transformation of elliptical nege-like virus Tanay virus2023DE-20JEOLJEM-2200FSBiologyCryoEMSingle-particle CryoEMJournal of General VirologyViewCryoEM and CryoET reveal new structural geometries of Tanay Virus, providing insights into the infection and assembly mechanism in negeviruses, which are common in mosquitos around the world
Synthesis, Characterization, and Acute Cytotoxicity Evaluation of Chloroquine Encapsulating Liposomes2023DE-12JEOLJEM-2010FBiologyCryoEMLow-dose HRTEMMicroViewCryoEM helped to characterize the size and shape of Liposomes encapsulating chloroquine, a widely used malaria drug. These results may be relevant for liposome-based chloroquine delivery for nanomedicine applications.
Lipid-coated mesoporous silica nanoparticles for anti-viral applications via delivery of CRISPR-Cas9 ribonucleoproteins2023DE-20JEOLJEM 2200FSBiologyCryoEMSingle-particle CryoEMScientific ReportsViewThis study reports the use of Lipid-coated mesoporous silica nanoparticles to deliver CRISPR-Cas9 ribonucleoproteins (RNPs) that target the Niemann–Pick disease type C1 gene, reducing Ebola virus infection
Factors Influencing the Repeated Transient Optical Droplet Vaporization Threshold and Lifetimes of Phase Change, Perfluorocarbon Nanodroplets 2023DE-20JEOLJEM-2200FSMaterialsCryoEMLow-dose HRTEMNanomaterialsViewImaging of perfluorocarbon nanodroplets
Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species2022DE-64TFSTitan HaloBiologyOtherResin-embedded TomographyDisease Models and MechanismsViewElectron tomography used to investigate microvesicles released from mamallian photoreceptor cells
Capsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family Portrait 2022DE-64, ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMVirusesViewCapsid structure of two parvoviruses determined by single particle CryoEM
Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles2022DE-64JEOLCryoARM300BiologyCryoEMCryo Electron TomographyNature MicrobiologyViewUnbinned (8k x 8k) counting CryoET with DE-64. Hybrid virus particles (HVPs) of influenza A virus (IAV) and respiratory syncytial virus (RSV) harbour surface glycoproteins and ribonucleoproteins of IAV and RSV for immune evasion.
ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures2022DE-64JEOLCryoARM300BiologyCryoEMMicroEDPNASViewNew model of disease-associated mutations in T cell intracellular antigen-1 (TIA-1) with potential to elucidate the molecular mechanisms of neurodegenerative diseases caused by amino acid mutations in intrinsically disordered proteins
Characterizing the Resolution and Throughput of the Apollo Direct Electron Detector2022ApolloTFSTitan KriosBiologyCryoEMSingle-particle CryoEMJ Struct Bio XViewFirst single particle cryoEM data published with Apollo. Apollo outperformed competing detectors in comparative tests
Large Area, High Resolution Mapping of Approximate Rotational Symmetries in a Pd77.5Cu6Si16.5 Metallic Glass Thin Film2022Celeritas XSTFSTitan 200/80Materials4D STEMSymmetry mappingUltramicroscopyViewFirst 4D STEM publicaton using Celeritas. High resolution symmetry mapping of local order in a metallic glass
A mechanism for exocyst-mediated tethering via Arf6 and PIP5K1C-driven phosphoinositide conversion2022DE-64JEOLCryoARM300BiologyCryoEMCryo Electron TomographyCurrent BiologyViewCryo electron tomography of of exocyst-mediated liposome tethering
Cryoem Structure Determination of Actin Decorated with Smooth Muscle Heavy Meromyosin2022DE-64TFSTitan KriosBiologyCryoEMSingle-particle CryoEMSSRN PreprintViewDetermination of the 3-D structure of F-actin in complex with recombinant smooth muscle heavy meromyosin in the presence of Mg·ADP
Isolation and Characterization of Lytic Proteus Virus 3092022DE-16TFSTecnai F20BiologyOtherNegative Stain TEMVirusesViewHighly lytic bacteriophage, Proteus_virus_309 imaged using a DE-16
Emerging Disordered Layered-Herringbone Phase in Organic Semiconductors Unveiled by Electron Crystallography2022DE-64JEOLCryoARM300MaterialsCryoEMMicroEDChem MaterViewMicroED on a DE-64 of an organic semiconductor material
Switchable wetting of oxygen-evolving oxide catalysts2022DE-16JEOLJEM 2200FSMaterialsIn situLiquid phase EMNature CatalysisViewIn situ electrochemistry on wettability of an oxide (with zero-loss energy filtering)
Reversed Phase Transformation of β→α-Sn at Elevated Temperatures towards Quantum Material Integration on Silicon2022DE-16JEOLARM 200FMaterials4D STEMCrystal phase mappingCommunications MaterialsViewExample of crystal phase mapping with 4D STEM on a DE-16 camera.
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site2022DE-20JEOLJEM-F200BiologyCryoEMScreeningScience AdvancesView
Size Distribution of Inactivated Tick-Borne Encephalitis Virus Particles Revealed by a Comprehensive Physicochemical Approach2022DE-20JEOLJEM-2100BiologyCryoEMLow-dose HRTEMBiomedecinesView
Comparing Two Methods for the Isolation of Exosomes2022DE-20JEOLJEM-2200FSBiologyCryoEMLow-dose HRTEMJournal Of Nucleic AcidsView
Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity2022DE-20TFSKriosBiologyCryoEMSingle-particle CryoEMJournal Of VirologyView
Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase2022DE-20TFSTecnai TF20BiologyCryoEMCryo Electron TomographyThe Embo JournalView
Methods and Applications of Campenot Trichamber Neuronal Cultures for the Study of Neuroinvasive Viruses2022DE-20JEOLJEM-2200FSBiologyCryoEMCryo Electron TomographyAxonalView
Alphavirus Particles Can Assemble with an Alternate Triangulation Number2022DE-20JEOLJEM-3200FSCBiologyCryoEMSingle-particle CryoEMVirusesView
Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses2022DE-20JEOLJEM-2200FSBiologyCryoEMCryo Electron TomographyJournal Of VirologyView
Characterization of a Primordial Major Capsid-Scaffolding Protein Complex in Icosahedral Virus Shell Assembly2022DE-20JEOLJEM-2200FSBiologyCryoEMSingle-particle CryoEMJournal Of Molecular BiologyView
Rigid monoclonal antibodies improve detection of SARS-CoV-2 nucleocapsid protein2021DE-12TFSTecnai F20BiologyOtherNegative Stain TEMmAbsViewTEM used to visualize monoclonal antibodies that can bind to the SARS-COV-2 virus
Machine learning-based real-time object locator/evaluator for cryo-EM data collection2021DE-64JEOLCryoARM300BiologyCryoEMComputational methodsNature Communications BiologyViewDevelopment of Machine Learning applied to automate cryoEM data collection with a DE-64
High temporal-resolution scanning transmission electron microscopy using sparse-serpentine scan pathways2021None (DE-Freescan)JEOLARM 200FMultipleIn situSTEM imagingScientific ReportsViewDemonstration of Serpentine STEM scanning and sparse sampling with DE-Freescan as techniques for faster in situ STEM imaging
Fast Surface Dynamics on a Metallic Glass Nanowire2021DE-16TFSTitan 300/80MaterialsIn situIn situ HeatingACS Nano ViewRapid In situ heating with a DENS holder.
Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV 2021DE-16TFSTecnai F20BiologyOtherNegative Stain TEMVaccinesViewVirus-like particles imaged with a DE-16 during HIV vaccine candidate study
Electron crystallography of chiral and non-chiral small molecules2021DE-64TFSTalos Arctica 200BiologyCryoEMMicroEDUltramicroscopyView3D structures of chiral and non-chiral small organic molecules solved using continuous rotation MicroED on a DE-64
Ultrafast electron microscopy for probing magnetic dynamics2021DE-16JEOLJEM 2100 UTEMPhysicsOtherUltrafast TEMMRS BulletinViewExample of Ultrafast 4D STEM mapping of a magnetic field.
Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes2021DE-12JEOLJEM 3200FSBiologyCryoEMSingle-particle CryoEMJournal of VirologyViewAnalysis of the structure of spike proteins on the surface of alphavirus particles, which may guide future antiviral drug design
In situ electron microscopy study of structural transformations in 2D CoSe22021DE-16TFSTitan 300/80MaterialsIn situIn situ Heatingnpj 2D MaterialsViewIn situ heating at atomic resolution showing phase change in Cobalt Di-Selenide
Direct Detectors and Their Applications in Electron Microscopy for Materials Science2021DE-16, DE-SEMCamMultipleMultipleMaterialsOtherReviewJournal of Physics : MaterialsViewReview article on direct detectors in materials science electron microscopy
Elemental mapping of labelled biological specimens at intermediate energy loss in an energy-filtered TEM acquired using a direct detection device2021DE-12JEOLJEM 3200EFBiologyCryoEMEFTEM elemental mappingJournal of MicroscopyViewDemonstration of low dose elemental mapping of biological specimens with a DE-12 (aka DirectView)
The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the Vesivirus genus2021DE-64JEOLCryoARM300BiologyCryoEMSingle-particle CryoEMJournal of VirologyViewDetermination of the of the 3D capsid structure of Vesivirus 2117, a contaminant in biopharmaceutical manufacturing
The myosin II coiled-coil domain atomic structure in its native environment2021DE-64TFSTitan KriosBiologyCryoEMSingle-particle CryoEMPNASViewCryo-EM structure of the α-helical coiled-coil tail of Myosin II, the molecule that produces force in muscle contraction
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo2021DE-64TFSTitan KriosBiologyCryoEMSingle-particle CryoEMNature CommunicationsViewStudy of trans-translation inhibitors as a potential therapy for drug-resistant bacteria
Three-step nucleation of metal–organic framework nanocrystals2021DE-16JEOLJEM 2200FSMaterialsIn situ Liquid phase EMPNASViewExtreme Low Dose In Situ TEM of MOFs
A data reduction and compression description for high throughput time-resolved electron microscopy2021DE-16JEOLJEM 2200FSMaterialsIn situ Computational methodsNature CommunicationsViewAdvanced algorithms for high speed in situ TEM
Protein and Organic-Molecular Crystallography With 300kV Electrons on a Direct Electron Detector2021DE-64JEOLCryoARM300BiologyCryoEMMicroEDFrontiers in Molecular BiosciencesViewDemonstration of low dose electron diffraction (MicroED) on a DE-64
Real-time Monitoring Reveals Dissolution/Redeposition Mechanism in Copper Nanocatalysts during the Initial Stages of the CO2 Reduction Reaction2021DE-16JEOLJEM 2200FSMaterialsIn situLiquid phase EMAngewandte ChemieViewIn situ TEM of Carbon Dioxide Reduction over Copper Nanocatalysts
Sub-3 Å Cryo-EM Structures of Necrosis Virus Particles via the Use of Multipurpose TEM with Electron Counting Camera2021DE-20JEOLJEM-2100FBiologyCryoEMSingle-particle CryoEMInternational Journal Of Molecular SciencesView
Below 3 Å structure of apoferritin using a multipurpose TEM with a side entry cryoholder2021DE-20JEOLJEM-2200FSBiologyCryoEMSingle-particle CryoEMScientific ReportsView
Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids2021DE-20JEOLJEM-2200FSBiologyCryoEMLow-dose HRTEMPharmaceuticalsView
Regulation of reversible conformational change, size switching, and immunomodulation of RNA nanocubes2021DE-20JEOLJEM-2200FSBiologyCryoEMSingle-particle CryoEMRNAView
Flagellar Structures from the Bacterium Caulobacter crescentus and Implications for Phage ϕCbK Predation of Multiflagellin Bacteria2021DE-20JEOLJEM-2200FSBiologyCryoEMCryo Electron TomographyJournal Of BacteriologyView
Supertwisted spirals of layered materials enabled by growth on non-Euclidean surfaces2020DE-16TFSTitan 300/80Materials4D STEMCrystal orientation mappingScienceViewTwist angles of 2D layers in a layered 2D material determined using nanodiffraction on a DE-16
CryoEM structure of Drosophila flight muscle thick filaments at 7 A resolution2020DE-64TFSTitan KriosBiologyCryoEMSingle-particle CryoEMLife Science AllianceView
Mechanism of efficient double-strand break repair by a long non-coding RNA2020DE-64JEOLJEM 2200FSBiologyCryoEMSingle-particle CryoEMNucleic Acids ResearchView
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¹Figure adapted from Huang, S., et al. (2024) Nanoscale View of Alignment and Domain Growth in a Hexagonal Columnar Liquid Crystal, The Materials Data Facility DOI: 10.18126/c8ng-h428

²Figure adapted from the Electron Microscopy Data Bank (EMDB), entry ID EMD-48650

³Figure adapted from Della Ventura et al. Ultramicroscopy 268, 114079 (2025) under CC BY 4.0 license

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