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Discover how automated crystal selection, data collection, and structure determination are making MicroED more accessible.
Microcrystal electron diffraction (MicroED) enables researchers to determine the structures of small molecules, peptides, and proteins using crystals too small for conventional X-ray crystallography. However, traditional MicroED workflows often require considerable operator expertise to identify suitable crystals, optimize data collection, and acquire high-quality diffraction datasets.
What if much of that process could happen automatically?
Join Direct Electron for a free webinar exploring REyes (Reciprocal Eyes), a fully autonomous MicroED platform designed to streamline the entire workflow, from crystal selection through structure determination.
REyes uses diffraction-based screening to evaluate crystals across a sample grid, identifying promising candidates based on their diffraction quality rather than appearance alone.
Once suitable crystals are identified, the system automates targeting and tilt-series acquisition, enabling structure determination with minimal operator intervention.
By integrating with SerialEM and supporting different TEM configurations, REyes offers researchers a practical pathway toward autonomous MicroED without requiring specialized microscope hardware.
During this webinar, our presenters will discuss:
Diffraction-guided crystal selection: How REyes identifies promising crystals based on diffraction quality.
Automated data collection: How crystal targeting and tilt-series acquisition can be performed without continuous operator involvement.
Performance and results: How autonomous MicroED compares with expert manual data collection, including examples of high-resolution structural determination.
Practical implementation: How REyes integrates with SerialEM and can be deployed across different TEM systems.
Jose Rodriguez — University of California, Los Angeles (UCLA)
Hosea Nelson — California Institute of Technology (Caltech)
Dmitry Eremin — California Institute of Technology (Caltech)
Together, the presenters will explore the development, capabilities, and practical applications of autonomous MicroED, highlighting opportunities to improve throughput, consistency, and accessibility in electron diffraction experiments.
Autonomous MicroED with REyes
Tuesday, November 10, 2026
9:00 AM PST | 12:00 PM EST | 6:00 PM CET
Discover how autonomous MicroED is helping researchers obtain high-quality diffraction data while reducing the time and expertise required for structure determination.